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Vol. 20: Fall 2002
Genetic Considerations in Thrombotic Disorders
This issue of the Genetic Drift is dedicated to the memory of our Montana colleague, Karen Streets, member and avid supporter of the Mountain States Genetics Network for the past 12 years. Karen served on the prenatal committee and her spirit lives on through her many contributions to quality prenatal screening for the network laboratories.
From the Editor and Authors:
The fall 2002 Genetic Drift deals with a broad range of topics around the common theme of thrombotic disorders. Primary care providers are already well aware of the importance of adult thrombotic disease and we provide a comprehensive state-of-the-art review by a clinical geneticist who is also an internist. Pediatric thrombotic disorders are increasingly recognized and a complete review, including diagnosis and management, is provided by a pediatric hematologist. Researchers in clinical genetics and child neurology are just beginning to appreciate the role of thrombophilia in fetal loss and neonatal stroke, and recently published investigations in this area are summarized by a pediatric clinical geneticist. The Teratogen Hot Topic for this issue is, naturally, a compilation of the anticoagulants commonly used during pregnancy. The issue ends with a discussion of genetic counseling for heterozygosity for the common factor V Leiden mutation.The articles in this issue were authored by Matthew Taylor, MD (CO), Prasad Mathew, MD (NM), Terri Grebe, MD (AZ), Lynn Martinez (UT), Katherine Berry, MS, CGC (MT) and Elaine Spector, PhD (CO).
Carol L. Clericuzio, MD (NM), Editor
Genetic Considerations in Thrombotic Disorders
Table of Contents
Introduction
Adult Thrombotic Disorders
Pediatric Thrombotic Disorders
Fetal and Neonatal Effects of Maternal/Fetal Thrombotic Disorders
Teratogen Hot Topic: Anticoagulants
Heterozygote Counseling for Factor V Leiden mutation
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