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Teratogen Update Vol. 12: Fall, 1995

• General

  Gunderson S et al. (1990): Critical Review of Articles Regarding Pregnancy Exposures in Popular Magazines. Teratology 42:469-472.

• Medications

  Manasse HR Jr (1989): Medication Use in an Imperfect World. Drug Misadventure as an Issue of Public Policy. ASHP Research and Education Foundation pp 1-3.

  Rubin P (1990): Prescribing in Pregnancy. The Practitioner 234:556-560.

  • ACE Inhibitors

    Barr M (1994): Teratogen Update: Angiotensin-Converting Enzyme Inhibitors. Teratology 50:399-409.

  • Anticonvulsants

    Gilman AG, Rall TW, Nies AS, Taylor P (1990) "The Pharmacologic Basis of Therapeutics." McGraw-Hill, Inc.

    Kelly TE (1984): Teratogenicity of Anticonvulsant Drugs; II: A Prospective Study. Am J Med Genet 19:435-43.

    Dansky LV, Finnell RH (1991): Parental Epilepsy, Anticonvulsant Drugs and Reproductive Outcome: Epidemiologic and Experimental Findings Spanning Three Decades; 2: Human Studies. Reproductive Toxicology 301-335.

    Briggs G, Freeman R, Yaffe S (1994): "Drugs in Pregnancy and Lactation." Williams & Wilkins.

• Substance Abuse

  • Alcohol

    Davis WL, Crawford LA, Cooper OJ, Farmer GR, Thomas DL, Freeman BL (1990): Ethanol induces the generation of reactive free radicals by neural crest cells in vitro. J Craniofacial Genet Devel Biol 10:277-293.

    Earnhart CB et al. (1987): Alcohol teratogenicity in the human: A detailed assessment of specificity, critical period, and threshold. Am J Obstet Gynecol 156:33-39.

    Schenker S et al. (1990): Fetal alcohol syndrome: Current status of pathogenesis. Alcohol Clin Exp Res 14:635-647.

    Sulik KK et al. (1986): Fetal alcohol syndrome and DiGeorge anomaly; Critical ethanol exposure periods for craniofacial malformations as illustrated in an animal model. Am J Med Genet (suppl) 2:97-112.

  • Toluene

    Arnold G, Wilkins-Haug L (1990): Toluene embryopathy syndrome. Am J Hum Genet 47:A46.

    Hersh JH (1989): Toluene embryopathy: Two new cases. J Med Genet 26:333-337.

    Holmberg PC (1979): Central-nervous-system defects in children born to mothers exposed to organic solvents during pregnancy. Lancet 2:177-179.

    Pearson MA, Hoyme HE, Seaver LH, Rimeza ME (1994): Toluene embryopathy: Delineation of the phenotype and the comparison with fetal alcohol syndrome. Pediatrics 93:211-215.

    Toutant C, Lippman S (1979): Fetal solvent syndrome. Lancet 1:1356.

    Wilkins-Haug L, Gabow PA (1991): Toluene abuse during pregnancy: Obstetric complications and perinatal outcomes. Obstet Gynecol 77:505-509.

  • Cocaine

    Chasnoff IJ, Bussey ME, Savich R et al. (1986): Perinatal cerebral infarction and maternal cocaine use. J Pediatrics 108:456-459.

    Downing GJ, Horner SR, Kilbride HW (1991): Characteristics of perinatal cocaine-exposed infants with necrotizing enterocolitis. Am J Dis Child 145:26-27.

    Hoyme HE, Jones KL, Dixon SD, Jewett T, Hanson JW, Robinson LK et al. (1990): Prenatal cocaine exposure and fetal vascular disruption. Pediatrics 85:743-747.

    Kapur RP, Shaw CM, Shepard TH (1991): Brain hemorrhages in cocaine exposed human fetuses. Teratology 44:11-18.

    Miller BM, Rosario PG, Prakash K, et al. (1990): Neonatal intestinal perforation: the "crack" connection. Am J Gastroenterol 85767-85769.

    Shaw GM, Malcoe LH, Lammer EJ (1991): Maternal use of cocaine during pregnancy and congenital cardiac anomalies. J Pediatr 118:167-168.

    Webster WS, Brown-Woodman ODC (1990): Cocaine as a cause of congenital malformations of vascular origin: Experimental evidence in the rat. Teratology 41:689-697.

• Maternal Infections

  Remington J, Klein J (1990): "Infectious Diseases of the Fetus and Newborn Infant." W.B. Saunders, Co.

  Seaver L, Hoyme HE (1992): Teratology on Pediatric Practice. Pediatric Clinics of North America 39.

  Hanshaw J, Dudgeon J, Marshall W (1985): "Viral Diseases of the Fetus and Newborn." 2nd edition, W.B. Saunders.

  Fowler K, Stango S, Pass R, Britt W, Boll T, Alford C (1992): The Outcome of Congenital Cytomegalovirus Infection in Relation to Maternal Antibody Status. N Engl J Med 326:663-667.

  Centers for Disease Control (1989): Risks Associated with Human Parvovirus B19 Infection. Morbidity and Mortality Weekly Report 38:81-87.

  American Academy of Pediatrics Committee in Infectious Diseases (1990): Parvovirus, erythema infectiosum, and pregnancy. Pediatrics 85:131.

  Pastuszak A, Levy M, Schick B, Zuber C, Feldkamp M, Gladstone J, Bar-Levy F, Jackson E, Donnenfeld A, Meschino W, Koren G (1994): Outcome After Maternal Varicella Infection in the First 20 Weeks of Pregnancy. N Engl J Med 330:901-905.

  Jones KL, Johnson K, Chambers C (1994): Offspring of Women Infected With Varicella During Pregnancy: A Prospective Study. Teratology 49:29-32.

  ACOG Technical Bulletin (1992): HIV Infection. No. 165, March.

  Whitley R et al, (1991): Predictors of Morbidity and Mortality in Neonates With Herpes Simplex Virus Infections. N Engl J Med 423:450-454.

• Maternal Disorders

  • Phenylketonuria

    Luke B, Keith LG (1990): The Challenge of Maternal Phenylketonuria Screening and Treatment. J Repro Med 35:667.

    Hanley WB, Clarke JTR, Schoonhey W (1987): Maternal Phenylketonuria (PKU) - A Review. Clinical Biochemistry 20:149.

    Fisch RO, Burke B, Bass J et al. (1986): Maternal Phenylketonuria - Chronology of the Detrimental Effects on Embryogenesis and Fetal Development: Pathological Report, Survey, Clinical Application. Pediatric Pathology 5:449.

  • Diabetes Mellitus

    York R, Brown LP, Swank A et al. (1990): Diabetes Mellitus in Pregnancy: Clinical Review. J Perinat X(3):285.

    Landon MB, Gabbe SG (1992): Diabetes Mellitus and Pregnancy. Obstetrics and Gynecology Clinics of North America 19:633.

    Sadler TW, Hunter ES, Balkan W et al. (1988): Effects of Maternal Diabetes on Embryogenesis. Am J Perinat 5:319.

    Mimouni F, Tsang RC (1988): Pregnancy Outcome in Insulin-Dependent Diabetes: Temporal Relationships with Metabolic Control During Specific Pregnancy Periods. Am J Perinat 5:334.

    Becerra JE, Khoury MJ, Cordero JF, et al. (1990): Diabetes Mellitus During Pregnancy and the Risks for Specific Birth Defects: A Population-based Case-Control Study. Pediatrics 85:1.

  • Systemic Lupus Erythematosus and Antiphospholipid Antibodies

    Hayslett JP (1992): The Effect of Systemic Lupus Erythematosus on Pregnancy Outcome. Am J Repro Immun 28:199.

    Brown HL (1991): Antiphospholipid Antibodies and Recurrent Pregnancy Loss. Clinical Obstetrics and Gynecology 34:17.

    Petri M (1994): Systemic Lupus Erythematosus and Pregnancy. Rheumatic Disease Clinics of North America 20:87.

    Lockshin MD (1992): Overview of Lupus Pregnancies. Am J Repro Immun 28:181.

  • Mutagens

    Fuscoe JC, Zimmerman LJ, Lippert JJ et al. (1991): V(D)J recombinase-like activity mediates hprt gene deletion in human fetal T-lymphocytes. Cancer Res 51:6001-6005.

    Manchester DK, Parker NB, Bowman CM (1984): Maternal smoking increases aryl hydrocarbon hydroxylase activity in human placenta but not umbilical vein endothelium. Pediatr Res 18:1071-1075.

    Manchester DK, Jacoby EH (1984): Decreased placental monooxygenase activities associated with birth defects. Teratology 30:31-38.

    Manchester DK, Weston A, Choi J-S et al. (1988): Detection of benzo(a)pyrene diol epoxide-DNA adducts in human placenta. Proc Natl Acad Sci 85:9243-9247.

    McGinniss JJ, Falta MT, Sullivan LM, Albertini RJ (1990): In vivo hprt mutant frequencies in T cells of normal human newborns. Mutation Res 240:117-126.

    Russell WL, Oakberg EF (1963): The cellular basis and aetiology of the late effects of irradiation on fertility in female mice. Cellular Basis and Aetiology of Late Somatic Effects of Ionizing Radiation (RJC Harris, ed) 224-232 New York, Academic Press.

    Russell LB, Russell WL (1954): An analysis of the changing radiation response of the developing mouse embryo. J Cell Comp Physiol 43:103-149.

The Genetic Drift Newsletter is not copyrighted. Readers are free to duplicate all or parts of its contents. The Genetic Drift Newsletter is published semiannually by the Mountain States Genetics Network for associates & those interested in Human Genetics. In accordance with accepted publication standards, we request acknowledgement in print of any article reproduced in another publication. The views expressed in the newsletter do not necessarily reflect local, state, or federal policy. For additional information, contact Carol Clericuzio, M.D., Editor, Department of Pediatrics, The University of New Mexico, Albuquerque, NM, 87131

Teratogen Update Table Of Contents:
Introduction
Medications
Substances of Abuse
Maternal Infections
Maternal Disorders
Mutagens
Etiology of Congenital Malformations in Humans: (Table 1)
Known Human Teratogens: (Table 2)
References
Facts About Neural Tube Defects and Folic Acid

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